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Results for "

mitochondrial complex

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Mitochondrial Metabolism (28) ADC Cytotoxin (1) AMPK (2) Antibiotic (6) Apoptosis (18) ATP Synthase (2) Autophagy (2) Bacterial (3) Biochemical Assay Reagents (3) Calcium Channel (1) Caspase (1) CDK (2) ClpP (1) Cytochrome P450 (3) Endogenous Metabolite (6) Fungal (8) Hexokinase (2) HIV (4) HSP (1) Isotope-Labeled Compounds (4) Mixed Lineage Kinase (2) Na+/K+ ATPase (1) NF-κB (4) Oxidative Phosphorylation (6) Paraptosis (1) Parasite (7) Phosphatase (1) Potassium Channel (2) Reactive Oxygen Species (8) RIP kinase (2) Sodium Channel (1) Topoisomerase (1) β-catenin (1)
By Research Areas:	Cancer (35) Cardiovascular Disease (2) Infection (22) Inflammation/Immunology (7) Metabolic Disease (4) Neurological Disease (5)

By Targets:

Mitochondrial Metabolism (28)

ADC Cytotoxin (1)

AMPK (2)

Antibiotic (6)

Apoptosis (18)

ATP Synthase (2)

Autophagy (2)

Bacterial (3)

Biochemical Assay Reagents (3)

Calcium Channel (1)

Caspase (1)

CDK (2)

ClpP (1)

Cytochrome P450 (3)

Endogenous Metabolite (6)

Fungal (8)

Hexokinase (2)

HIV (4)

HSP (1)

Isotope-Labeled Compounds (4)

Mixed Lineage Kinase (2)

Na+/K+ ATPase (1)

NF-κB (4)

Oxidative Phosphorylation (6)

Paraptosis (1)

Parasite (7)

Phosphatase (1)

Potassium Channel (2)

Reactive Oxygen Species (8)

RIP kinase (2)

Sodium Channel (1)

Topoisomerase (1)

β-catenin (1)

By Research Areas:

Cancer (35)

Cardiovascular Disease (2)

Infection (22)

Inflammation/Immunology (7)

Metabolic Disease (4)

Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Mitochondrial Metabolism Mitophagy Arp2/3 Complex

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130055

HQNO 1 Publications Verification	Mitochondrial Metabolism	Infection
HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a K_d of 64 nM for complex III . HQNO is a potent inhibitor of mitochondrial NDH-2 in many species .

HY-W194810

MCU-i11	Mitochondrial Metabolism	Neurological Disease Metabolic Disease
MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca ²⁺ uptake. MCU-i11 impairs muscle cell growth .

HY-155556

ZG36	ClpP Biochemical Assay Reagents	Cancer
ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model .

HY-150966

Antiproliferative agent-10	Mitochondrial Metabolism
Antiproliferative agent-10 (compound 8) is an anti-tumour ruthenium(II)-tris-pyrazolylmethane complex that inhibits the growth of cancer cells by inhibiting mitochondrial calcium uptake .

HY-150969

Antiproliferative agent-12	Mitochondrial Metabolism	Cancer
Antiproliferative agent-10 (compound 1) is an anti-tumour ruthenium(II)-tris-pyrazolylmethane complex that inhibits the growth of cancer cells by inhibiting mitochondrial calcium uptake .

HY-155554

SCAL-255	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
SCAL-255 is a potent mitochondrial complex I (CI) inhibitor with IC₅₀ of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-255 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells .

HY-155555

SCAL-266	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC₅₀ of 0.83 μM. SCAL-266 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-266 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells .

HY-B0825A

Fenpyroximate	Parasite Mitochondrial Metabolism	Infection
Fenpyroximate is an acaricide and insecticide against many mites and insect pests of agricultural crops and ornamentals. Fenpyroximate is also a strong inhibitor of *bovine heart mitochondrial* NADH-ubiquinone oxidoreductase (complex I)**, binds to the ND5 subunit .

HY-155474

Me4Phen	Apoptosis	Cancer
Me4Phen (compound 3) is an oxygen rhenium (V) complex that depletes mitochondrial membrane potential and upregulates intracellular reactive oxygen species (ROS), leading to endoplasmic reticulum stress-mediated necrosis of cancer cells. Me4Phen is highly lipophilic and effectively overcomes Cisplatin (HY-17394) resistance in a variety of cancer cells .

HY-112037

IACS-010759 5+ Cited Publications IACS-10759	Oxidative Phosphorylation Mitochondrial Metabolism Apoptosis	Cancer
IACS-010759 is an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 has the potential for relapsed/refractory AML and solid tumors research .

HY-112037A

IACS-010759 hydrochloride 5+ Cited Publications IACS-10759 hydrochloride	Oxidative Phosphorylation Mitochondrial Metabolism Apoptosis	Cancer
IACS-010759 hydrochlorideis an orally active, potent mitochondrial complex I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 hydrochlorideinhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 hydrochloride has the potential for relapsed/refractory AML and solid tumors research .

HY-131334

AMPK activator 4	AMPK	Metabolic Disease
AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect .

HY-110282

S3QEL-2	Oxidative Phosphorylation Mitochondrial Metabolism	Metabolic Disease
S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC₅₀=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation .

HY-B1756

Rotenone Maximum Cited Publications 54 Publications Verification	Mitochondrial Metabolism Autophagy Apoptosis	Neurological Disease Cancer
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-112177

Myxothiazol	Fungal Mitochondrial Metabolism Antibiotic	Infection
Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain **complex III (bc1 complex)** inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml .

HY-18733

Lipoic acid 5+ Cited Publications (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid	Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species	Inflammation/Immunology Cancer
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-131958

D942

AMPK Cancer

D942 is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, D942 inhibits cell growth .

D942	AMPK	Cancer
D942 is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, D942 inhibits cell growth .

HY-121214

Amisulbrom	Mitochondrial Metabolism	Infection
Amisulbrom is a sulfonamide fungicide used to control oomycete diseases. Amisulbrom biochemically inhibits the cytochrome-bc1 complex of the mitochondrial electron transport system .

HY-138301

Miclxin DS37262926	β-catenin	Cancer
Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex .

HY-163337

Antifungal agent 92	Fungal	Infection
Antifungal agent 92 (Compound 21) is a potent antifungal agent with an EC₅₀ of 4.4 μM against Sclerotinia sclerotiorum. Antifungal agent 92 can induce abnormal mitochondrial morphology, loss of mitochondrial membrane potential, and reactive oxygen species (ROS) accumulation in Sclerotinia sclerotiorum. Antifungal agent 92 is a moderate promiscuous inhibitor of mitochondrial complexes II and III .

HY-163077

Anticancer agent 175	Reactive Oxygen Species Apoptosis	Cancer
Anticancer agent 175 (complex 1) ia a near-infrared (NIR) luminescent theranostic complex. Anticancer agent 175 induces ROS accumulation, mitochondrial damage, disruption of Bax/Bcl-2 equilibrium, and tumor cell apoptosis in HepG2 cell line .

HY-136093B

Lixumistat IM156 free base; HL156A free base; HL271 free base	Mitochondrial Metabolism	Cancer
Lixumistat (IM156) is a novel *biguanide mitochondrial* protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS*) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial* metabolic reprogramming and inhibit lung fibrosis. Lixumistat also suppresses B-cell activation to alleviate systemic lupus erythematosus .

HY-B0817

Pyridaben
Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC₅₀ value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .

HY-N2877

Annonacin	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel	Neurological Disease
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex. Annonacin is the active agent found in Annona muricata to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps .

HY-125637

Venturicidin B Aabomycin A2	Fungal ATP Synthase	Infection
Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP synthase complex .

HY-126222

MitoTam bromide, hydrobromide	Apoptosis Mitochondrial Metabolism	Cancer
MitoTam bromide, hydrobromide, a Tamoxifen derivative , is an electron transport chain (ETC) inhibitor. MitoTam bromide, hydrobromide reduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam bromide, hydrobromide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells .

HY-112715

ATP synthase inhibitor 1	ATP Synthase	Cardiovascular Disease
ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F₁/F_O-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels .

HY-13832

Atovaquone 1 Publications Verification Atavaquone	Parasite Cytochrome P450 Antibiotic Bacterial	Infection Cancer
Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1* complex. Atovaquone is against human and P. falciparum* cytochrome bc1 activity with IC₅₀ values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia .

HY-18733R

Lipoic acid (Standard) 5+ Cited Publications (R)-(+)-α-Lipoic acid(Standard); R-(+)-Thioctic acid (Standard)	Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species	Inflammation/Immunology Cancer
Lipoic acid (Standard) is the analytical standard of Lipoic acid. This product is intended for research and analytical applications. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-126222A

MitoTam iodide, hydriodide	Apoptosis Mitochondrial Metabolism	Cancer
MitoTam iodide, hydriodide is a Tamoxifen derivative , an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells . MitoTam iodide, hydriodide causes apoptosis .

HY-135549

Fluxapyroxad	Fungal Antibiotic	Infection
Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. It works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species .

HY-155063

TRAP1-IN-1	HSP Mitochondrial Metabolism	Cancer
TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1，a mitochondrial isoform of Hsp90. TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94，and disrupts TRAP1 tetramer stability，induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS，disrupts the mitochondrial membrane potential，and enhances glycolysis metabolism .

HY-124726

Aumitin	Autophagy	Neurological Disease Cancer
Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC₅₀s of 0.12 μM and 0.24 μM, respectively .

HY-B0817S

Pyridaben-d13	Parasite	Infection
Pyridaben-d₁₃ is the deuterium labeled Pyridaben[1]. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function[2][3].

HY-114936

Piericidin A AR-054	Bacterial ADC Cytotoxin Antibiotic Mitochondrial Metabolism	Infection Neurological Disease Cancer
Piericidin A (AR-054) is a natural mitochondrial *NADH-ubiquinone oxidoreductase (complex* I)** inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity .

HY-113607

Asimicin Bullatacin	Mitochondrial Metabolism Parasite	Infection Cancer
Asimicin (Bullatacin) is antitumor acetogenin that can be isolated from the bark and seeds of the pawpaw tree, Asimina trilobal Dunal. Asimicin inhibits mitochondrial respiration through the inhibition of complex I. Asimicin shows toxicity to Aphis gossypii, mosquito larvae and mammalian .

HY-13832S2

Atovaquone-d5 Atavaquone-d₅	Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic	Infection
Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-13832S3

cis-Atovaquone-d4 cis-Atavaquone-d₄	Isotope-Labeled Compounds Parasite Cytochrome P450 Antibiotic	Infection
cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-D0190

2-Thenoyltrifluoroacetone 1 Publications Verification HTTA; TTA; TTFA	Biochemical Assay Reagents	Infection Others Cancer
2-Thenoyltrifluoroacetone is a chelating agent. 2-Thenoyltrifluoroacetone can be used for the complexation of various metal ions including Mn(II), Co(III), Ni(II), et al.. 2-Thenoyltrifluoroacetone possesses antitubercular and cytotoxic activities. 2-Thenoyltrifluoroacetone is also used as common inhibitor of mitochondrial electron flux and to analyze the endothelial cell dysfunction. Besides, copper (II) complex of 2-Thenoyltrifluoroacetone has anticancer activity against K562 .

HY-B0849

Azoxystrobin	Fungal Reactive Oxygen Species Apoptosis Bacterial Phosphatase	Infection
Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis .

HY-B0849S

Azoxystrobin-d4	Isotope-Labeled Compounds Fungal Reactive Oxygen Species Apoptosis	Infection
Azoxystrobin-d₄ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

HY-B0486

Lonidamine 5+ Cited Publications AF-1890; Diclondazolic Acid; DICA	Hexokinase Mitochondrial Metabolism Apoptosis Parasite	Inflammation/Immunology Cancer
Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (K_i: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis .

HY-B0849S1

Azoxystrobin-d3	Fungal Reactive Oxygen Species Apoptosis	Infection
Azoxystrobin-d₃ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis[1].

HY-B0849R

Azoxystrobin (Standard)	Fungal Reactive Oxygen Species Apoptosis	Infection
Azoxystrobin (Standard) is the analytical standard of Azoxystrobin. This product is intended for research and analytical applications. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

HY-121577

Sonlicromanol KH176	Reactive Oxygen Species	Metabolic Disease
Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease .

HY-156622

Leramistat HMC-C-01-A; MBS2320	Mitochondrial Metabolism	Cancer
Leramistat (HMC-C-01-A; MBS2320) is a mitochondrial complex 1 inhibitor, involving in cell metabolism immune metabolism regulation. Leramistat also inhibits ATP production in Thp1 human monocytes (IC₅₀: 0.63 μM). Leramistat inhibits atopic dermatitis and other skin diseases autoimmune diseases, inflammatory diseases, cancer; and also inhibits osteoclast mediated disease .

HY-N0492S

α-Lipoic Acid-d5 Thioctic acid-d₅; (±)-α-Lipoic acid-d₅; DL-α-Lipoic acid-d₅	Isotope-Labeled Compounds NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

HY-13721

Phenoxodiol 1 Publications Verification Idronoxil; Dehydroequol; Haginin E	Caspase Apoptosis Topoisomerase	Cancer
Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21 ^WAF1 via a p53 independent manner .

HY-148365

NecroIr1	Mixed Lineage Kinase RIP kinase CDK	Cancer
NecroIr1 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr1 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase (MLKL), and regulates CDK4 expression .

HY-101180

C2 Ceramide 1 Publications Verification Ceramide 2
C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-130055

HQNO 1 Publications Verification	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Mitochondrial Metabolism
HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a K_d of 64 nM for complex III . HQNO is a potent inhibitor of mitochondrial NDH-2 in many species .

HY-B1756

Rotenone Maximum Cited Publications 54 Publications Verification	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Leguminosae Derris trifoliata Lour. Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Mitochondrial Metabolism Autophagy Apoptosis
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-112177

Myxothiazol	Infection Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Disease Research Disease Research Fields Other Antibiotics	Fungal Mitochondrial Metabolism Antibiotic
Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain **complex III (bc1 complex)** inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml .

HY-18733

Lipoic acid 5+ Cited Publications (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-N2877

Annonacin	Natural Products Neurological Disease Classification of Application Fields Annona muricata Linn. Source classification Plants Annonaceae Disease Research Fields	Potassium Channel Sodium Channel Na+/K+ ATPase Calcium Channel
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex. Annonacin is the active agent found in Annona muricata to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps .

HY-18733R

Lipoic acid (Standard) 5+ Cited Publications (R)-(+)-α-Lipoic acid(Standard); R-(+)-Thioctic acid (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Mitochondrial Metabolism Endogenous Metabolite Reactive Oxygen Species
Lipoic acid (Standard) is the analytical standard of Lipoic acid. This product is intended for research and analytical applications. Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

HY-114936

Piericidin A AR-054	Structural Classification Neurological Disease Classification of Application Fields Source classification Anti-parasitic Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Anticancer Disease Research Fields	Bacterial ADC Cytotoxin Antibiotic Mitochondrial Metabolism
Piericidin A (AR-054) is a natural mitochondrial *NADH-ubiquinone oxidoreductase (complex* I)** inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity .

HY-N0492

α-Lipoic Acid 5 Publications Verification Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

α-Lipoic Acid sodium Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	Infection Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492R

α-Lipoic Acid (Standard) 5 Publications Verification Thioctic acid (Standard); (±)-α-Lipoic acid (Standard); DL-α-Lipoic acid (Standard)	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of *mitochondrial* enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

Species:	Human (6) Mouse (1)
Tag:	His (6) SUMO (3) GST (1)
Source:	P. pastoris (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P71088

	UQCRH Protein, Human (GST) Cytochrome b-c1 complex subunit 6; mitochondrial; complex III subunit 6; complex III subunit VIII; Cytochrome c1 non-heme 11 kDa protein; mitochondrial hinge protein; Ubiquinol-cytochrome c reductase complex 11 kDa protein	Human	E. coli
	UQCRH is an important component of the mitochondrial electron transport chain and contributes to oxidative phosphorylation within the ubiquinol-cytochrome c oxidoreductase complex. It operates in the respiratory chain, transferring electrons from NADH and succinate to molecular oxygen, establishing an electrochemical gradient for ATP synthesis. UQCRH Protein, Human (GST) is the recombinant human-derived UQCRH protein, expressed by E. coli , with N-GST labeled tag. The total length of UQCRH Protein, Human (GST) is 91 a.a., with molecular weight of 33-45 kDa.

HY-P72098

	ATP5D Protein, Human (His) ATP synthase subunit delta; mitochondrial ; ATP synthase subunit delta; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; delta subunit; ATP5D; ATPD_HUMAN; F ATPase delta subunit ; F-ATPase delta subunit; mitochondrial ATP synthase complex delta subunit precusor ; mitochondrial ATP synthase delta subunit	Human	E. coli
	ATP5D Protein, a vital component of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. As part of the F(1) domain and central stalk, ATP5D contributes to ATP hydrolysis through a rotary mechanism. The ATP synthase complex, involving ATP5D, is pivotal for cellular energy production via ATP synthesis. ATP5D Protein, Human (His) is the recombinant human-derived ATP5D protein, expressed by E. coli , with N-10*His labeled tag. The total length of ATP5D Protein, Human (His) is 146 a.a., with molecular weight of ~20 kDa.

HY-P72095

	ATP5F1A Protein, Human (His) ATP synthase alpha chain; ATP synthase alpha chain; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit 1; cardiac muscle; ; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 2; alpha subunit; ATP5A; Atp5a1; ATP5AL2; ATPA_HUMAN; ATPM; hATP1; HEL-S-123m; MC5DN4; mitochondrial;	Human	E. coli
	ATP5F1A is an important component of mitochondrial ATP synthase (complex V) that coordinates ATP production from ADP by utilizing the transmembrane proton gradient. As part of the F-type ATPase, the α and β subunits of ATP5F1A form the catalytic core to achieve ATP hydrolysis. ATP5F1A Protein, Human (His) is the recombinant human-derived ATP5F1A protein, expressed by E. coli , with N-6*His labeled tag. The total length of ATP5F1A Protein, Human (His) is 510 a.a., with molecular weight of ~59.2 kDa.

HY-P72097

	ATP5D Protein, Human (His-SUMO) ATP synthase subunit delta; mitochondrial ; ATP synthase subunit delta; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; delta subunit; ATP5D; ATPD_HUMAN; F ATPase delta subunit ; F-ATPase delta subunit; mitochondrial ATP synthase complex delta subunit precusor ; mitochondrial ATP synthase delta subunit	Human	E. coli
	ATP5D Protein, a vital component of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. As part of the F(1) domain and central stalk, ATP5D contributes to ATP hydrolysis through a rotary mechanism. The ATP synthase complex, involving ATP5D, is pivotal for cellular energy production via ATP synthesis. ATP5D Protein, Human (His-SUMO) is the recombinant human-derived ATP5D protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of ATP5D Protein, Human (His-SUMO) is 146 a.a., with molecular weight of ~31 kDa.

HY-P72096

	ATP5F1A Protein, Human (His-SUMO) ATP synthase alpha chain; ATP synthase alpha chain; mitochondrial; ATP synthase subunit alpha; ATP synthase subunit alpha mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit 1; cardiac muscle; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; 1; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 1; cardiac muscle; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 2; non-cardiac muscle-like 2; ATP sythase F1 ATPase; alpha subunit; ATP5A; Atp5a1; ATP5AL2; ATPA_HUMAN; ATPM; Epididymis secretory sperm binding protein Li 123m; hATP1; HEL-S-123m; MC5DN4; mitochondrial; mitochondrial ATP synthetase; mitochondrial ATP synthetase oligomycin resistant; Modifier of Min 2; Modifier of Min 2 mouse homolog; Modifier of Min 2; mouse; homolog of; MOM2; OMR; ORM; OTTHUMP00000163475	Human	E. coli
	ATP5F1A is an important component of mitochondrial ATP synthase (complex V) that coordinates ATP production from ADP by utilizing the transmembrane proton gradient. As part of the F-type ATPase, the α and β subunits of ATP5F1A form the catalytic core to achieve ATP hydrolysis. ATP5F1A Protein, Human (His-SUMO) is the recombinant human-derived ATP5F1A protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of ATP5F1A Protein, Human (His-SUMO) is 510 a.a., with molecular weight of ~71.2 kDa.

HY-P71716

	ATP5F1B Protein, Human (P.pastoris, His) ATP 5B; ATP synthase H+ transporting mitochondrial F1 complex beta polypeptide; ATPB; ATPB_HUMAN; ATPMB; ATPSB	Human	P. pastoris
	ATP5F1B protein is an important component of mitochondrial membrane ATP synthase (complex V). ATP5F1B Protein, Human (P.pastoris, His) is the recombinant human-derived ATP5F1B protein, expressed by P. pastoris , with N-His labeled tag. The total length of ATP5F1B Protein, Human (P.pastoris, His) is 482 a.a., with molecular weight of ~53.8 kDa.

HY-P71567

	OGDC-E Protein, Mouse (His-SUMO) Ogdh; Kiaa4192; 2-oxoglutarate dehydrogenase; mitochondrial; EC 1.2.4.2; 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase	Mouse	E. coli
	The OGDC-E Protein, a vital component of the 2-oxoglutarate dehydrogenase complex, drives the conversion of 2-oxoglutarate to succinyl-CoA in the mitochondrion, a pivotal step in the Krebs cycle. It employs thiamine diphosphate for decarboxylation, connecting to the E2 enzyme and participating in nuclear histone succinylation with KAT2A. OGDC-E Protein, Mouse (His-SUMO) is the recombinant mouse-derived OGDC-E protein, expressed by E. coli, with N-SUMO, N-6*His labeled tag. The total length of OGDC-E Protein, Mouse (His-SUMO) is 329 a.a., with molecular weight of ~54 kDa.

Cat. No.	Product Name	Chemical Structure

HY-B0817S

Pyridaben-d13

Pyridaben-d₁₃ is the deuterium labeled Pyridaben[1]. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function[2][3].

HY-13832S2

Atovaquone-d5

Atovaquone-d₅ is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-13832S3

cis-Atovaquone-d4

cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-B0849S

Azoxystrobin-d4
Azoxystrobin-d₄ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

HY-B0849S1

Azoxystrobin-d3
Azoxystrobin-d₃ is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis[1].

HY-N0492S

α-Lipoic Acid-d5
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

Cat. No.	Product Name	Application	Reactivity

HY-P81071

DLST Antibody 2-oxoglutarate dehydrogenase complex component E2; Dihydrolipoamide S succinyltransferase (E2 component of 2 oxo glutarate complex); Dihydrolipoamide S succinyltransferase; Dihydrolipoamide succinyltransferase component of 2 oxoglutarate dehydrogenase complex; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; Dihydrolipoyllysine residue succinyltransferase component of 2 oxoglutarate dehydrogenase complex; Dihydrolipoyllysine residue succinyltransferase component of 2 oxoglutarate dehydrogenase complex mitochondrial; Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; Dlst; DLTS; E2; E2K; mitochondrial; ODO2_HUMAN; OGDC-E2.	WB; ELISA; IHC-P; IHC-F; ICC; IF;	Human, Mouse (predicted: Rat, Rabbit, Pig, Sheep, Cow, Dog, Horse)
DLST Antibody is an unconjugated, approximately 41 kDa, rabbit-derived, anti-DLST polyclonal antibody. DLST Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF, expriments in mouse and predicted: human, rat, dog, pig, cow, horse, rabbit, sheep background without labeling.

HY-P81835

SDHB Antibody (YA1580)

SDHB; SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit; mitochondrial; Iron-sulfur subunit of complex II; Ip
WB, IHC-P, IP, FC Human, Mouse, Rat
HY-P82790

NDUFS1 Antibody (YA2535)

NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit; mitochondrial; complex I-75kD; CI-75kD
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P82184

Complex III Subunit 2 Antibody (YA1929)

Core protein II; QCR2; mitochondrial; Ubiquinol cytochrome c reductase core protein II; UQCR2; Uqcrc2
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P81601

NDUFS3 Antibody (YA1346)

NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3; mitochondrial; complex I-30kD; CI-30kD; NADH-ubiquinone oxidoreductase 30 kDa subunit
WB Human, Mouse

HY-P80878

Pyruvate Dehydrogenase E1 alpha Antibody (YA681) mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; PHE1A; Pyruvate Dehydrogenase (lipoamide) alpha 1; Pyruvate dehydrogenase complex; E1 alpha polypeptide 1; Pyruvate Dehydrogenase E1 alpha; Pyruvate dehydrogenase E1 com	WB, ICC/IF	Human, Mouse
Pyruvate Dehydrogenase E1 alpha Antibody (YA681) is a non-conjugated and Mouse origined monoclonal antibody about 43 kDa, targeting to Pyruvate Dehydrogenase E1 alpha (3H2). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse.

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